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Figure 6


Fig. 6. Loss of PKC{epsilon} results in a reduced ability of fibroblasts to migrate on extracellular matrix. (A) As described in the Materials and Methods, migration was measured using a scratch wound assay. PKC{epsilon}+/+ and PKC{epsilon}-/- fibroblasts were cultured on fibronectin until confluence, and a linear scrape was made across the cell layer. Migration was monitored for the times indicated. Three independent experiments were performed Gap size expressed as a percentage of the original wound is shown (average±standard deviation) (*P<0.05 relative to wild-type control). (B) Migration was monitored as in A, in the presence and absence of added TGFβ1 (4 ng/ml). Quantitiative densitometry data are indicated on the right. Gap size expressed as a percentage of the original wound is shown (average±s.d.), *P<0.05 relative to wild-type control. Three independent experiments were performed.





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