spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 3


Fig. 3. Contribution of oxidative phosphorylation and glycolysis to ATP production in activated M{Phi}. Total cellular [ATP] and ATP synthesis rates (glycolytic and mitochondrial) of M{Phi} treated with IFN{gamma} + LPS (A) and IFN{gamma} + LPS + SEITU (B) are shown. Treatment with SEITU prevented the drop in mitochondrial synthesis of ATP and reduced the enhanced glycolytic production of ATP in activated M{Phi}. It also prevented the drop in total cellular [ATP]. Cellular [ATP] was determined by the luciferase assay, the rate of synthesis of ATP by glycolysis was computed from the lactate production rate, and the rate of synthesis of ATP by mitochondria was computed from the oligomycin-sensitive mitochondrial oxygen consumption rate, assuming a P:O ratio of 1:2.4. *, Total cellular ATP significantly different from values in non-activated cells (0 hour). Results are mean±s.d., n=5.





Right arrow Return to article