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Figure 2


Fig. 2. Mos and the APC/C in the regulation of CSF activity. (A) The Mos pathway, which includes the apical kinase Mos and the downstream kinases MEK, MAPK and Rsk, was shown to be crucial for CSF arrest. However, the link between Rsk and CSF required clarification. (B) CSF was manifested as an inhibition of the APC/C and stabilization of Cdc2–cyclin-B. (C) Taking A and B together, it was postulated that Rsk might work through the APC/C to regulate CSF. However, the link between Rsk and the APC/C was initially unclear.





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