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Fig. 9. CblA, PTP3 and cellular signalling. This scheme suggests that the apparent downregulation of PTP3 by CblA leads to a stimulation in the DIF-induced tyrosine phosphorylation of STATc. In the case of stress the strong negative effect engendered by osmotic stress, probably mediated by increased serine threonine phosphorylation, is not relieved by CblA. The cblA– has morphological phenotypes, similar to those of `DIF-less' mutants, such as the dimB-null strains. We suggest, therefore that both PTP3 and the DIF synthesis and response genes impinge at a common point to regulated morphogenesis. However, CblA is not necessary for DIF responsiveness of ecmA or for DimB activation, hence the proposed dichotomy.
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