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Figure 7


Fig. 7. Controlled TCPTP activation inhibits VEGF-driven sprouting angiogenesis. (A,B) HUVEC spheroids embedded in three-dimensional collagen gel were treated with VEGF (20 ng/ml) and 400 nM TAT peptides as indicated. Spheroids were analyzed after 24 hours at 10x magnification (A) and the cumulative sprout length (A, bottom) and the number of sprouts per spheroid (B) were quantified using image analysis. Shown is a representative of two similar experiments (mean ± s.e.m., n=5 spheroids per treatment). (C) PAE spheroids embedded in three-dimensional collagen gel were treated with VEGF (20 ng/ml) and 400 nM TAT peptides as indicated. Spheroids were analyzed after 24 hours at 10x magnification and the cumulative sprout length was quantified using image analysis. Shown is a representative of two similar experiments (mean ± s.e.m.; n=5 spheroids per treatment).





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