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Figure 5


Fig. 5. Hypothesis for the mode of action of the ligand. Application of REV-ERB{alpha} ligand to the circadian cycle of REV-ERB{alpha} protein (A, green) causes the early decline of Bmal1 levels (black). At phase X in A (red box), this leads to an advance in the next Bmal1 cycle (red in B), as demonstrated in Fig. 4B. At phase Y (blue box), a delay results from the same treatment (blue in B), as seen in Fig. 4A.





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