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Figure 4


Fig. 4. Possible functions of CD34-family proteins: chemokine-mediated trafficking and regulation of asymmetric cell division. (A) Model of podocalyxin-dependent chemotaxis. (B) Two proposed mechanisms by which podocalyxin might facilitate asymmetric cell division. Segregation of podocalyxin to the apical surface might enable the interaction of adhesion molecules with the stem-cell niche; after division, only the cell that remains in contact with the niche would receive signals to maintain pluripotency. Alternatively, podocalyxin- and NHERF1-dependent segregation of cell-fate determinants might instruct the cell to divide asymmetrically.





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