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Figure 2


Fig. 2. The flagellar pocket exhibits a modified shape and accumulates vesicles in IFTRNAi mutant cells with a short or no flagellum. (A-F) Sections through the flagellar pocket region of wild-type (WT) trypanosomes (A), of the indicated IFTRNAi mutant cell lines (B-E) or of PF20RNAi cells (F) that were induced for 72 hours. The typical flask-shape of the flagellar pocket is altered and vesicles frequently accumulate in the lumen (D,E). A, anterior side of the flagellar pocket; P, posterior side; K, kinetoplast; BB, basal body; TR, transition region. Black arrows indicate the tight contact between the top of the flagellar pocket and the flagellum, the white arrow indicates a vesicle in the flagellar compartment and the arrowheads indicate excessive IFT material typical of retrograde transport defects. (G) Quantification of sections with the indicated phenotypes in wild-type (WT) and various IFTRNAi cell lines. WT, n=73; DHC1bRNAi, n=51; IFT140RNAi, n=36; IFT88RNAi, n=28; IFT172RNAi, n=31.





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