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Figure 4


Fig. 4. Ultrastructure of lens fibre cells in mutant mice. (A,B) EM of vimentin aggregates in lens fibre cells of 11-week-old VimR113C mice. Vimentin aggregates appear amorphous with sharp boundaries and are not surrounded by membranes. At this stage, the plasma membrane is not yet strongly affected. (C,D) Notice the highly pleated organisation of the plasma membrane in Vim{Delta}C2B mice. (D) Vimentin aggregates and membrane reorganisation in Vim{Delta}C2B mice at high resolution. Aggregates are dense, different in size and not attached to or enclosed by a membrane. Arrowheads mark irregular membrane invaginations. (E) Semi-thin section of a lens from a 22-week-old Vim{Delta}C2B transgenic mouse. An arrow marks the disrupted basal lamina of the lens capsule. Lens fibres break through basal lamina and protrude into the vitreous body. Scale bars: 2 µm (A) 1 µm (B, D), 3 µm (C), 20 µm (E).





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