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Fig. 8. Normal focal adhesions in fibroblasts expressing VimR₁₁₃C. Double immunofluorescence of focal adhesion proteins in wt and VimR₁₁₃C 3T3L1 fibroblasts. (A,C) Interaction of vimentin with talin and vinculin at the focal adhesions (arrow in inset). (B,D) Unaltered localisation of talin and vinculin in the presence of cytosolic vimentin aggregates (arrows). (E,G) Colocalisation of vinculin and talin with β1-integrin at focal adhesions. (F,H) Localisation of talin and vinculin at focal adhesions, marked by β1-integrin is unaltered in VimR₁₁₃C-expressing fibroblasts. These data suggest that VimR₁₁₃C-containing IFs are unable to interact stably with focal adhesions. Scale bar: 20 µm.

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