spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 2


Fig. 2. TDP-43 nuclear-cytoplasmic shuttling seen by interspecies heterokaryon assays. Transiently transfected U2OS cells were fused with mouse NIH-3T3 cells upon cycloheximide treatment. Arrows indicate mouse nuclei of the fused cell, distinguished from human nuclei using DAPI staining. (A,B) GFP-tagged as well as FLAG-tagged TDP-43 were analyzed in transfected U2OS or HeLa cells. (C,D) FLAG-tagged hnRNP A1 and hnRNP C1/C2 were used as a controls for protein shuttling. In the case of hnRNP C1/C2, GFP-TDP-43 and FLAG-hnRNP C1/C2 were co-transfected to observe specific TDP-43 shuttling in the same fused cell. Scale bars: 10 µm.





Right arrow Return to article