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Figure 5


Fig. 5. unc-94/tmd-1(RNAi) enhances the formation of actin aggregates in profilin-mutant backgrounds. (A) Frequency of adult worms that have actin aggregates in the body-wall muscle. Adult worms were stained with tetramethyl-Rhodamine–phalloidin, and worms with actin aggregates in their muscle were scored. Wild-type, pfn-2(null) and pfn-3(null) single mutants, and a pfn-3 pfn-2 double mutant were treated with control dsRNA or unc-94/tmd-1(RNAi). (B) Actin filament organization in the body-wall muscle of wild-type (a,b), pfn-2(null) (c,d), pfn-3(null) (e,f) and pfn-3(null) pfn-2(null) (g,h) treated with control dsRNA (a,c,e,g) or unc-94/tmd-1(RNAi) (b,d,f,h).





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