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Fig. 2. The absence of uPAR delays keratinocyte migration and proliferation in vivo. (A) uPAR-wt and -KO paraffin-embedded cross-sections of 3-day-old wounds stained with hematoxylin and eosin. The length of the epidermal tongue was measured blindly at x10 magnification in eight sections per wound in eight mice per genotype by computer-assisted morphometry from the tip of the epidermal tongue (black arrowhead) to the start of the proliferating keratinocyte zone (blue arrowhead). (B) uPAR-wt and -KO paraffin-embedded cross-sections of 5-day-old wounds were immunostained using an anti-PCNA antibody and counterstained with hematoxylin. Measurements of PCNA-positive nuclei are reported. The numbers (± s.d.) refer to the average of eight wounds per genotype. (C) wt and uPAR-KO frozen cross-sections of 15-day-old wounds stained for keratin 5 (K5) are shown. Arrows indicate the thickness of the epidermis.

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