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Figure 1


Fig. 1. Spatial changes in lamina organization during cellular senescence in hMSCs. Changes in the spatial organization of lamin A during senescence of hMSCs. Cells at passage 3 were transduced with the lamin A-EGFP lentiviral vector and cultured for 9 passages. (A) Confocal images were taken from living cells at passage 4, 6, and 12 (PS 4, PS 6 and PS 12, respectively). Maximum projections of x-y and y-z axes from representative nuclei (left). Cross-sections 55 nm deep were made from the y-z axis. Shown are five serial sections at equal intervals (right). (B) Electron microscope images of horizontal (i,ii) or vertical (iii,iv) sections of hMSCs at passage 9, taken from normal (i,iii) or senescent cells (ii,iv). N, nucleus.





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