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Figure 4


Fig. 4. AQP4 knockout impairs neuronal differentiation of ANSCs. (A) ANSCs derived from SVZ could generate into neurons (TUJ1), astrocytes (GFAP) and oligodendrocytes (GalC) after 7 days of culture in differentiation medium. Scale bar: 100 µm. (B,C) The proportion of TUJ1+ cells in the Aqp4–/– cell population was significantly lower than that of Aqp4+/+ cells (*P<0.05, n=3). Scale bar: 50 µm. (D) No significant difference was found in the proportion of GFAP+ cells between Aqp4–/– and Aqp4+/+ cell populations.





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