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Figure 5


Fig. 5. Immunofluorescence analysis of XA024 MEFs. The genotypes are shown above panels; wt, wild type; het, heterozygous; hmz, homozygous. (A-C) Analysis with anti-RanGAP1 antibody. There is decreased nuclear rim staining in the homozygote (C) compared with the wild type (A) or heterozygote (B). (D-F) Analysis with anti-SUMO1 antibody. Staining in wild type (D) and heterozygote (E) is predominantly nuclear and nuclear rim. There is no staining above background in homozygote (F). (G-H) Analysis with anti-Sentrin 2 (SUMO3) antibody. There is no change in staining intensity or pattern in hetero- (H) and homozygotes (I) compared with the wild type (G). (J-L) Analysis with anti-PML antibody. Fewer PML nuclear bodies are observed in homozygote (L) compared with the wild type (J) and heterozygote (K).





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