spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 4


Fig. 4. Nuclear and cytoplasmic PTEN signaling. PTEN localizes to both the cytoplasm and the nucleus and shuttles between each by a variety of mechanisms. PTEN function is, at least in part, determined by its subcellular localization. The `classic' PTEN function is cytoplasmic and includes downregulation of AKT, which increases p27 levels and thereby leads to apoptosis. By contrast, nuclear PTEN has a variety of functions: downregulation of MAPK (ERK), leading to a decrease in cyclin D1 levels and G0-G1 arrest; upregulation of RAD51 levels and double-stranded-break repair; an interaction with CENP-C, which enhances centromere stability specifically and overall genomic stability; and apoptosis.





Right arrow Return to article