spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 1


Fig. 1. ECM-mediated effects on matrix remodeling. The 3D matrix environment stimulates integrin-mediated FN assembly through inhibiting a Raf1-mediated signaling pathway. Activation of integrin {alpha}5β1 by uPAR and its P25 ligand also stimulates FN assembly in combination with EGFR via a Src-kinase-mediated pathway. Activation of PTEN by 3D collagen contraction converts a FAK/PI3K-mediated survival signal into a pro-apoptotic signal. Activation of RhoA, presumably ECM-mediated, leads to assembly of a myosin II ring that facilitates FN unfolding during FN fibrillogenesis. SPARC stimulates FN unfolding and assembly using an ILK-dependent pathway.





Right arrow Return to article