spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 4


Fig. 4. ECM-mediated effects on stem cells within the bone marrow stem cell niche. The ECM regulates stem cell attachment and quiescence via integrins and HSPs. Osteopontin participates in regulating quiescence by interacting with integrins and CD44. Notch-jagged and KitL-Kit signaling also maintain quiescence. MMP cleaves the transmembrane form of KitL to create sKitL, which interacts with Kit as a dimer to activate HSCs. Integrins participate in the mobilization of progenitor cells.





Right arrow Return to article