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Figure 2


Fig. 2. Papp as a function of PEG radius in Caco-2, MDCK II and MDCK C7 monolayers and ex vivo pig ileum. All cell types show a size-restrictive pore calculated to be of radius ~4 Å. Ileum appears to have an additional pore cut-off at ~6.5 Å. In contrast to their similar size pore, the number of pores (reflected in the Papp<4 Å) is highly variable. Caco-2 cells have the largest numbers of pores as well as the greatest permeation through the size-independent pathway; MDCKII cells have an intermediate number and MDCK C7 cells have few pores and little permeation through the second pathway. T84 cells (data not shown) had a variable pore number, depending on the source of the cell line. The relative pore number in pig ileum cannot be compared with that of cell lines because of the difference in the amplified surface area in intact tissue compared with the flat cultured cell monolayers.





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