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Figure 9


Fig. 9. Model for the role of Ent3p, epsinR and SNAREs in endosomal traffic. In yeast (upper panel), Ent3p is required for traffic from the TGN to late endosomes. The ENTH domain of Ent3p interacts with Vti1p, Pep12p and Syn8p, which form a SNARE complex together with Ykt6p in traffic from the TGN to the late endosome. Ent3p functions in cargo sorting of Pep12p in traffic from the TGN to late endosomes (dashed arrow). In mammalian cells, epsinR is involved in retrograde traffic from the early endosome to the TGN. EpsinR interacted with Vti1b, syntaxin 7 (Syx7) and syntaxin 8 (Syx8), which have been implicated in homotypic fusion of late endosomes in a complex with VAMP8 and with VAMP7 transport from late endosomes to lysosomes. It has not been studied whether epsinR also functions in TGN to late endosome traffic.





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