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Figure 7


Fig. 7. EPHA2 recruits Src kinase to regulate adherens junction stability. Association of EPHA2 with Src kinase was measured by an MBP-EPHA2 pull-down assay (A) and coimmunoprecipitation and western blot analysis (B). (C,D) Inhibition of Src activity restores adherens junction stability in MCF-10A-EPHA2 cells. (E) Co-immunoprecipitation of EPHA2 and Src from COS7 cells transfected with Src and wild-type or mutant EPHA2. (F,G) Overexpression of EPHA2-Y812F and EPHA2-Y816F mutants in MCF-10A cells fails to destabilize adherens junction, even after 8 hours of Ca2+ depletion. (I-L) Overexpression of wild-type LMW-PTP is sufficient to destabilize adherens junctions in MCF-10A-Y812F and MCF-10A-Y816F cells.





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