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Figure 3


Fig. 3. IRSp53 is involved in Rac1-mediated ruffling but not Cdc42-mediated formation of filopodia in macrophages. (A) Representative images of F-actin-stained mock- or IRSp53-shRNA-treated nontransfected (top panel), or transfected to express either Myc/Rac1Q61L (middle panel) or Myc/Cdc42V12 (bottom panel), RAW/LR5 cells are shown where cells were stained for Myc to identify expressing cells. Bar, 10 µm. The ability of mock- (white bars) or IRSp53-shRNA-treated (gray bars) cells to exhibit either ruffles following Rac1Q61L expression (B) or filopodia following Cdc42V12 expression (C) was quantified and expressed as a percentage of the total cells counted; n=3; *, P<0.05 compared with mock-shRNA-treated cells. Bar, 10 µm.





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