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Figure 1


Fig. 1. The membrane topologies of the four known components of the {gamma}-secretase complex: PS1, PEN2, APH1 and NCT. The arrow indicates the endoproteolytic cleavage site in hydrophobic region 7 of PS1, which generates the PS1 NTF-CTF heterodimer that is the active form. Red asterisks denote the position of the catalytic aspartate residues in TMD6 and TMD7 of PS1. TMDs that are involved in intermolecular interactions between {gamma}-secretase components are indicated with the mixed colours of the respective components.





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