spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 3


Fig. 3. Intra- and intermolecular interactions in the {gamma}-secretase complex. Given the hydrophobic nature of {gamma}-secretase, most prominent and primary interactions are likely to be governed through or include their TMDs and hydrophobic domains. Here we present a bird's eye view of the TMDs of PS1 (yellow), NCT (green), APH1 (blue) and PEN2 (red), including the reported intra- (grey arrows) and intermolecular (black arrows) interactions. Suggested interactions are shown by dotted arrows, such as intramolecular interactions in APH1 (via GxxG motifs in TMD4) and the as-yet-uncharacterised interaction domains for APH1 in PS1 and for NCT in APH1. Ectodomain interactions of NCT with APP-CTF are indicated with a green arrow (see text for details). The red sparkle denotes the catalytic aspartate dyad.





Right arrow Return to article