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Figure 5


Fig. 5. Morphological changes in gal3–/– enterocytes. Electron microscopy of enterocytes from wt (gal3+/+) and galectin-3 null mutant (gal3–/–) mice. Numerous intracellular vesicles and vacuoles are visible in some enterocytes of gal3–/– mice (B,E). Higher magnifications of the brush border and tight junction area (D,E,F) show no differences between wt and gal3–/– mice. Lateral membranes of enterocytes from wt mice depict typical interdigitations (G,H), whereas in gal3–/– mice, numerous infoldings and protrusions (I-L, arrows) are visible. The intracellular space between two adjacent cells is indicated by arrowheads. In M-O the focus is on the basal part of the basolateral membrane. Infoldings (arrows) are seen in the enterocytes of gal3–/– mice. Scale bars: 2 µm.





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