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Figure 7


Fig. 7. A scheme representing a possible mechanism by which POPX2 negatively regulates transcription from the SRE. An increase in G-actin level results in inhibition of transcription from the SRE. Two different types of stress fibres are induced; one by ROK (SFR) and the other by mDia (SFM). SFR is formed from the bundling of existing actin filaments (F-actin) with myosin. SFM formation is catalyzed by the actin-nucleation and -polymerization activities of mDia. Downregulation of PAK activity by POPX2 results in stabilization and accumulation of SFR, which leads to less free F-actin in the cell. The increased G-actin:F-actin ratio will then inhibit SRE transcription. mDia has a positive effect on actin polymerization and enhances SRE transcription. Our current study shows that POPX2 blocks mDia enhancement of SRE response by its interaction with the mDia protein.





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