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Figure 7


Fig. 7. Overexpression of LUMA has dominant-negative effects on NE structure. (A,B) V5-tagged full-length LUMA 1-400 (A) and Myc-tagged LUMA-truncation mutants (B) were overexpressed in HeLa cells and visualized by immunofluorescence with antibodies against V5 or Myc. The NE was stained by anti-emerin antibody, chromatin by DAPI. Panels labeled V5xDAPI and mycxDAPI are merged images of the respective individual images. Panels labeled Overlay show overlays of individual V5 or myc images with the emerin image (V5 or Myc, green; emerin, red; DAPI, blue). Scale bars, 5 µm. Additionally, a schematic representation of the LUMA variants is shown.





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