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Figure 2

Figure 2


Fig. 2. The distribution of the eight loci (13q14, 15c, 16q12, 18c, 21q22, 22q11.2, Xc and Yc) in the nuclei of various cell types. The y-axis represents the percentage of signals represented in each shell (1-5) after normalisation to take into account the nuclear counterstain (excluding sperm). Shell 1 (x-axis) represents the outermost shell and shell 5 the innermost (see Fig. 1). Thus, a graph with the highest peak in shell 1 compared with the other shells represents a signal found most often at the nuclear periphery; a graph with the highest peak in shell 5 represents a signal found most often at the nuclear centre. n, the number of signals scored. P values represent the results of chi-squared tests to establish whether a significant non-random pattern could be identified. P<0.05, significantly non-random (P<0.01, highly significant); NOT SIG, not significant (i.e. P>0.05). (A) Normal lymphocyte nuclei. (B) Nuclei of trisomy 13 lymphoblastoid cells. (C) Nuclei of cultured cells from amniotic fluid (chromosomally normal). (D) Sperm-head nuclei (chromosomally normal, fertile male). (E) Blastomere nuclei with no detectable abnormality (NDA group). (F) Aneuploid blastomere nuclei. (G) Chaotic blastomere nuclei. (H) Blastomeres trisomic for the chromosome measured (e.g. position of chromosome-13 locus in trisomy-13 cells).





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