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First published online February 20, 2008

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DC-SIGN dynamics in dendritic cells

During the immune response, immature dendritic cells use cell-surface receptors–such as the lectin DC-SIGN–to capture antigens, which are later processed and presented on the cell surface for recognition by T lymphocytes. However, the antigen-capture pathway can be exploited by HIV-1, which is recognised by DC-SIGN then taken up by the cell and delivered to lymph tissue, where it infects T lymphocytes. On page 634, Ken Jacobson and colleagues describe the organisation of DC-SIGN on the surface of dendritic cells. The authors show that, in live cells, DC-SIGN assembles into clusters (500-600 nm in size) on the cell surface. DC-SIGN accumulates at the leading edge of the cell, but individual clusters destined for endocytosis move rearwards before being internalised. Moreover, translocation of DC-SIGN away from the leading edge is rapid and linear, which is consistent with a motor-protein-driven mechanism. HIV-1 might, the authors propose, promote its own uptake by stimulating the rearward movement and subsequent endocytosis of the DC-SIGN clusters to which it binds. These results shed light on the process of antigen capture by dendritic cells.

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Related articles in JCS:

Distribution and lateral mobility of DC-SIGN on immature dendritic cells–implications for pathogen uptake

Aaron K. Neumann, Nancy L. Thompson, and Ken Jacobson
JCS 2008 121: 634-643. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?