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Figure 2


Fig. 2. Cadherin domain structure. Cadherins are single-pass transmembrane proteins that are synthesized with a signal peptide (SP) and pro-region (pro), which are removed during protein processing. The extracellular domain comprises five homologous repeats (EC1-EC5) that are bridged by calcium ions (Ca2+). The cytoplasmic domain binds to p120-catenin (p120ctn) near the plasma membrane and to β-catenin near the C-terminus. {alpha}-catenin binds to β-catenin to link the cadherin complex to the actin cytoskeleton. E-cadherin and N-cadherin domain structures are similar, as are their interactions with catenins.





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