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Figure 4


Fig. 4. Cadherin switching can influence many cellular activities. Shown are some of the changes in cellular behavior that can be induced by cadherin switching. N-cadherin interacts with the FGF receptor (FGFR) and stabilizes the receptor on the cell surface. N-cadherin increases tumor cell interactions with endothelial and mesenchymal cells. NHERF links N-cadherin to the PDGF receptor (PDGFR) via interactions with β-catenin in lamellipodia to increase cell motility. N-cadherin and R-cadherin increase steady-state levels of activated Rac and Cdc42, which promotes cell motility. N-cadherin and R-cadherin promote endocytosis of E-cadherin via competition for p120-catenin.





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