spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 4


Fig. 4. Grh expression results in altered cellular morphology and disrupts the distribution of integrins and cadherin. Dorsal views of control (A,B) and ASc381>grh (C-F) embryos stained with antibodies against βPS integrin (green, A-D; white, A'-D') and E-cadherin (magenta, A-E; white, A''-D'',E',F). (A-D) ASc381>grh cells have poor localisation and patchy accumulation of βPS integrin (e.g. arrows, C,C'), reduced βPS integrin levels at epidermal interface (arrowheads, C,C',D,D'), reduced co-localisation between βPS integrin and E-cadherin (compare B with D), and some mislocalisation of E-cadherin (e.g. arrows C''). (E,F) Defects in the epidermis include bunching (orange arrows) and splaying (green arrows) of epidermal cells, and a detachment between the epidermis and the amnioserosa. (E) Nuclei are visualised with DAPI.





Right arrow Return to article