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Figure 7


Fig. 7. Model for the establishment of PHE1 imprinting. In the central cell of the female gametophyte the FIS-PcG complex binds to a polycomb response element (PRE) in the promoter region of PHE1. The differentially methylated region (DMR) is unmethylated in the central cell of the female gametophyte and blocks transcription together with the FIS complex, resulting in stable PHE1 repression in the endosperm. The FIS complex is absent in pollen und the methylated DMR prevents silencing activity, causing the paternal allele to be active in the endosperm. In met1-mutant pollen, the DMR is demethylated and can block PHE1 expression. Whether this involves PcG complexes is currently not known. Maternal alleles are shown in red, paternal alleles in blue.





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