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First published online March 5, 2008

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The benefits of recycling

The precise localisation of proteins and lipids to myelin subdomains is crucial for myelin morphogenesis and neuronal function, but how oligodendrocytes regulate this process is largely unknown. Neuronal signals stimulate oligodendrocytes to adjust the relative levels of endocytosis and exocytosis of PLP, the major myelin protein. Eva-Maria Krämer-Albers and colleagues (p. 834) ask whether endocytic trafficking is common to myelin proteins and whether endosomal sorting of myelin components assists in myelin-domain formation. They focus on the myelin-membrane proteins PLP, MAG and MOG, and find that they are all internalised from the plasma membrane before ending up in the myelin sheet. These proteins follow distinct endocytic sorting pathways before being recycled into different regions within the myelin sheets. Biochemical data show that endocytosis of these proteins is required for sorting into distinct myelin-membrane fractions of different densities. Trafficking through the endosomal system, therefore, is an important requirement for sorting into different regions within the myelin sheet. The authors suggest that endocytic sorting and recycling contributes to the mechanism that establishes distinct myelin-membrane domains.

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Related articles in JCS:

Distinct endocytic recycling of myelin proteins promotes oligodendroglial membrane remodeling

Christine Winterstein, Jacqueline Trotter, and Eva-Maria Krämer-Albers
JCS 2008 121: 834-842. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?