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Figure 8


Fig. 8. Regulation of adhesion dynamics in dendritic cells by PGE2. PGE2 signalling, mediated by EP2 and EP4 receptors, leads to elevation of the level of cAMP, activation of RhoA and inactivation of Rac1. PGE2-mediated activation of RhoA promotes Rho-kinase activity and, subsequently, myosin-II-dependent contraction, leading to podosome dissolution and FA formation. By contrast, pathways leading to activation of Rac1 are known to promote podosome formation and induce cytoskeletal relaxation accompanied by a loss of FAs.





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