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Figure 4


Fig. 4. Clr6 HDAC mutations suppress APC/C mutants. (A) clr6 mutations, but not {Delta}clr3 or {Delta}hos2, suppress the ts growth of cut4-533 mutants. The indicated strains were spotted on YPD plates and incubated at the indicated temperatures. In nmt1-clr6HA cells, the expression of HA-tagged clr6+ gene under nmt1 promoter was repressed on YPD plates. (B) The temperature sensitivities of cut9-665, apc10-153 and apc10-666 mutants were suppressed by clr6-1 mutations. The indicated strains were spotted and incubated. (C) The growth and the frequency of mitotic arrest phenotypes of double mutants of cut4-533 and HDAC mutants at the restrictive temperature. The indicated strains were cultured at 26°C and shifted to 36°C. The cell number (left panel) and the frequency of the mitotic delay phenotype (right panel) were measured at the indicated time points.





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