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Figure 6


Fig. 6. Deletion of the MBD, interdomain region and the TRD impact mobility of MECP2. (A) Recovery kinetics of the domain-deleted mutant forms indicate that that the MBD, ID and TRD contribute to the mobility. (B) The t50 values for the domain-deleted proteins indicate increased mobility for the protein within heterochromatin domains for the {Delta}ID and {Delta}TRD proteins compared with WT. The t50 for the {Delta}MBD in nucleoplasm was intermediate between the value for euchromatin and heterochromatin for the WT protein (WT=21.3±5.4, {Delta}MBD=1.3±0.4, {Delta}ID=5.3±2.1 and {Delta}TRD=7.9±2.5). Asterisks represent t50 values that are significantly different from heterochromatin in WT (P<0.0001). Number of nuclei for each group is shown within each bar.





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