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Figure 7


Fig. 7. Common RTT mutations significantly impact mobility of MECP2. (A) Recovery profiles of MECP2e2 (WT) and common RTT mutations of MECP2 found in the patient population. Balbc/3T3 cells were transiently transfected with CMV driven expression constructs encoding N-terminus EGFP-tagged MECP2, including common RTT mutations. Photobleaching was performed in regions of nucleoplasm (R106W, F155S, T158M) or heterochromatin (R133C, R168X). (B) The t50 values of the WT and RTT mutants (WT=23.4±8.8, R106W=1.4±0.42, R133C=12.4±4.5, F155S=1.5±0.5, T158M=1.4±0.3 and R168X=1.17±0.5). The sample size for each group is given within the bars. Asterisks represent significant different values compared with the WT protein in heterochromatin (P<0.0001).





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