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Fig. 1. Destabilization of E-cadherin–catenin complexes from keratinocyte junctions. Normal human keratinocytes were microinjected with (a) Rac1Q61L and (b) Rac3G12V cDNA, expressed for different time points (2-8 hours) and stained with anti-Myc and anti-E-cadherin antibodies. Arrows indicate absence of E-cadherin. Arrowheads show thickening of E-cadherin staining in the middle of cell-cell contact areas. Scale bars, 20 µm.