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Figure 3


Fig. 3. Transgenic minigene expression is present in keratinocytes of the interfollicular epidermis and the hair follicle. (A-I) F1 line VF1-07 tetop-LAG608G+; K5tTA+. (J-L) FvB/N wild-type mice. (M-O) F1 line SF1-04 tetop-LAwt+; K5tTA+. Immunofluorescence with the cytokeratin 5 (CK5) antibody in green (A,G,J), human lamin A/C antibody in red (B,E,H,K,N) and DAPI (D,M). (C,F,I,L,O) Merged panels, including DAPI. Dorsal skin tissue sections from different ages of mice: 18 weeks (A-C), 9 weeks (D-F), 9 weeks end-stage (G-I), 4 weeks (J-L) and 22 weeks (M-O). (K) No staining with the human lamin A/C antibody to FVB/N wild-type dorsal skin shows that the antibody is specific to human lamin A/C. Transgenic mice were supplied with doxycycline until time of weaning – day 21. Scale bars: 50 µm.





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