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Figure 13


Fig. 13. siRNA-mediated suppression of PKC{epsilon} or PKC{zeta} inhibits EC tube morphogenesis. ECs were treated with the indicated siRNAs and were suspended in 3D collagen matrices for 24 hours before fixation for photography and quantification. (A) Representative fields of ECs treated with the indicated siRNAs. Bar, 50 µm. (B,C) Quantification of EC vasculogenesis assay at 24 hours. The data are shown as the mean number of EC lumens per HPF (B) or the mean EC lumenal area (Metamorph software) (C) ±s.d. (n=3). *, P<0.05 compared with the luciferase control. (D) EC lysates were prepared for western blot analysis and probed with antibodies against the indicated PKC isoforms or actin (control).





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