spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 14


Fig. 14. Schematic diagram illustrating Cdc42/Rac1- and PKC-mediated EC lumen and tube formation signaling pathways in 3D collagen matrices. There is an activation of Cdc42 and Rac1 in response to an interaction between collagen matrices and {alpha}2β1 integrins, which leads to the recruitment of the Par3-Par6b-PKC{zeta} polarity complex that regulates EC lumen and tube formation. Cdc42 and Rac1 also promote the phosphorylation of Pak2 and Pak4, which serve as downstream targets of PKC{epsilon} in response to TPA to stimulate EC lumen and tube formation in 3D collagen matrices.





Right arrow Return to article