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Figure 5


Fig. 5. siRNA suppression of Pak2 or Pak4 markedly blocks EC lumen and tube formation as well as EC invasion in 3D collagen matrices. (A) ECs transfected with the indicated siRNAs were suspended within collagen matrices for 48 hours before fixation for photography. Bar, 100 µm. (B) ECs transfected with the indicated siRNAs were allowed to invade for 24 hours in response to S1P before fixation for photography. Bar, 100 µm. (C) siRNA-transfected EC lysates were prepared for western blot analysis and probed for Pak2, Pak4 or beta-actin (control).





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