spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 2


Fig. 2. The core mechanisms of apical-basal cell polarity. Cell-polarity complexes that contain the Par3-Par6-aPKC protein complex (and the Crumbs-Pals1-Patj complex; not shown) localize to the apical membrane domain and promote apical membrane identity. The function of Par3-Par6-aPKC complex is counteracted by the Dlg, Scrib, Lgl and Par1 proteins that localize to the basal membrane domain, and promote basolateral-membrane-domain identity. aPKC counteracts the activity of basal polarity proteins via direct phosphorylation and `inactivation' of Lgl. Although the mechanisms that are responsible for negative regulation of Par3-Par6-aPKC activity by the Dlg, Scrib and Lgl proteins are not well understood, basal Par1 can negatively regulate the apical polarity complex by phosphorylation and inactivation of apical Par3.





Right arrow Return to article