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Fig. 2. Arp3^schwächling mutants stop myoblast fusion after precursor formation. (A-C) Anti-Eve stainings on stage-15 embryos visualize the nuclei of the DA1 muscle (arrow) and the pericardial cells (per). (A) The wild-type DA1 muscle contains up to 14 nuclei. (B) Since fusion is disturbed in homozygous Arp3^schwächling mutant embryos, the DA1 muscle only contains approximately three nuclei. (C) The DA1 muscle in Arp3^schwächling wasp^3D3-035 double mutants is mainly mono-nucleated, showing that myoblasts fail to fuse completely. (D) Statistical analysis of the DA1 nuclei confirms that Arp3^schwächling and wasp^3D3-035 single mutants stop fusion after precursor formation. However, in Arp3^schwächling wasp³ double mutants, no fusion takes place. (E,F) Electron microscopy studies on stage-14 wild-type embryos. (E) Assembly of the pre-fusion complex (arrow); (F) arrow marks the electron-dense plaque that is formed between two fusing myoblasts. N, cell nucleus. Magnifications: (E) 12,000x; (F) 21,000x.

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