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Figure 5


Fig. 5. The Arp2/3 regulators SCAR and the WASP-Vrp1 complex act in concert to regulate myoblast fusion in Drosophila. All embryos were stained with anti-β3-tubulin. (A-C) Lateral views of stage-16 embryos. (A) Homozygous scark13811 embryos hardly show fusion defects. (B) Unfused myoblasts (arrow) are observed in homozygous scark13811 mutant embryos that lack one copy of wasp3. (C) scark13811 wasp3 double-mutant embryos display lots of unfused myoblasts (arrow). (D-G) Dorsal views of stage-14/15 embryos. (D) Wild type. (E) Embryos that are homozygous for scar{Delta}37 display a weak fusion defect (arrow). Some muscles are missing (arrowhead) and dorsal closure is delayed. (F) vrp1f06715 mutant embryos stop fusion after precursor formation. (G) scar{Delta}37 vrp1f06715 double mutants exhibit a strong myoblast-fusion defect.





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