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Fig. 6. Vrp1 is expressed in discrete foci, but becomes localized in the filopodia upon cell-cell contact. (A-C) Stage-13/14 embryos stained with anti-Vrp1 antibody. (A'-C') Higher-magnification views of the boxed areas in A-C. (A) Embryo carrying the enhancer-trap insertion rP298 stained with anti-β-galactosidase and anti-Vrp1. Ventral view of a stage-14 embryo. (A') In round myoblasts, Vrp1 can be detected in discrete foci (asterisks). However, in FCMs that have formed a filopodium, Vrp1 is enriched at the tip of the FCM, which attaches to a growing myotube (arrow points towards the tip of a filopodium and the arrowhead marks a dinucleated precursor). Note that the precursor cell (arrowhead) also shows a weak expression of Vrp1. (B) sns^20-23-null mutant embryo at stage 13; lateral view. (B') Vrp1 is still present in discrete foci (asterisks); however, no localization of Vrp1 to the tip of a filopodium was observed. (C) Ventral view of a stage-14 wasp^3D3-035 Arp3^schwächling double-mutant embryo. (C') Vrp1 can be found in round myoblasts in discrete foci (asterisk) and in the tip of a filopodium (arrow). Scale bars: 10 µm.

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