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Figure 2


Fig. 2. Syntenin-dependent subcellular trafficking of receptors and regulation by Rab- and Arf-family GTPases. Black arrows indicate syntenin-controlled trafficking of proTGF{alpha} in the secretory route, syndecans and CD63 in the endosomal compartment and tethering of Delta1 at the plasma membrane; grey arrows indicate syntenin-independent trafficking. Inhibitory activity of syntenin for trafficking through a particular route is also indicated. The regulators Rab5, Rab7, Rab11 and Arf6 (indicated in bold) have been reported to bind and/or colocalize with syntenin. The major composition of phosphoinositol lipids that are present in a particular organelle is indicated by the colour scheme in the key. The question mark indicates contradictory results. EE, early endosome; ER, endoplasmic reticulum; LE, late endosome; MVB, multivesicular body; RE, recycling endosome; TGN, trans-Golgi network.





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