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Figure 4


Fig. 4. Transition from E12.5 to E13.5 results in extensive hyperplasia in {alpha}E-catenin–/– brains without significant changes in the expression of endogenous transcriptional targets of the β-catenin-signaling pathway. (A) Hyperplasia in E13.5 {alpha}E-catenin–/– mouse brains. Total cells were isolated from E12.5 and E13.5 heterozygous and {alpha}E-catenin–/– mouse brains and counted using a Coulter Counter. Data represent means ± s.d. n=3-5. *P<0.0001. (B) qPCR analysis of β-catenin pathway transcripts Myc, Ccnd1 (cyclin D1) and Axin2 in E12.5 and E13.5 heterozygous and {alpha}E-catenin–/– mouse brains. The levels of expression are shown in arbitrary units with mean of levels in heterozygous embryos adjusted to 1. Data represent means ± s.d. n=4.





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